Why do beta-blockers increase insulin resistance?

This means that beta-1–selective drugs are less likely to interfere with the secretion and regulation of insulin. Several studies have shown that a combination of beta-blockers and thiazide diuretics, as expected, also produces an increase in the risk of developing diabetes, by approximately 20%. read more

Older beta blockers have an effect on the way glucose is metabolized (taken up and used) by the body, but newer, more selective vasodilating beta blockers' positive effect (increasing blood flow) can partly make up for that issue. read more

But beta-blockers also block the release of insulin by interacting with nerve signals to the pancreas and can thus lower insulin levels even when blood glucose is high. There is some evidence that not all beta-blockers affect insulin secretion. Beta-blockers work by interacting with proteins in the body called beta receptors. read more