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Why do red blood cells have spikes when crenated?

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Acanthocyte (from the Greek word ἄκανθα acantha, meaning 'thorn'), in biology and medicine, refers to a form of red blood cell that has a spiked cell membrane, due to abnormal thorny projections. A similar term is spur cells. 2. read more

Instead, it is speculated that cell surface receptors on the red blood cells bind with HDL cholesterol which induces the shape change in echinocytes. Echinocytes are seen above. Notice how their thorny projections are short and regular, and have a central area of pallor. read more

Crenated red cells in blood smear: Crenated red cells in blood smear are abnormally contracted red blood cells that appear in a blood test. See detailed information below for a list of 5 causes of Crenated red cells in blood smear, including diseases and drug side effect causes. read more

artefactual crenation may be due to slow drying of the smear or aging of blood in the tube. Older red cells, whether aged in circulation or in the tube, are more likely to undergo the discocyte-echinocyte transformation than younger red cells. read more

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Why do red blood cells have spikes when crenated? - Quora
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