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Why does rapamycin decrease glycolysis?

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Rapamycin is an inhibitor of mTOR (mammalian target for rapamycin). Glycolytic enzymes such as glycolytic enzymes hexokinase II (HKII), glyceraldehyde 3-phosphate dehydrogenase (GAPDH), and lactate dehydrogenase-B (LDHB) are positively regulated by mTOR (Qian S. et al). read more

* mTOR inhibition negatively regulates glycolysis [1] * A typical cycle of glycolysis produces 2 ATP, 2 NADH, and 2 pyruvate molecules [2] * Hence inhibition of mTOR by rapamycin depletes this source of energy. read more

Glycolysis in major tissues in relation to diabetes (A) In type 1 diabetes, insulin insufficiency leads to a decrease in rates of glycolysis in key tissues involved in the regulation of systemic glucose homeostasis. read more

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How is Glycolysis Regulated?
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