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Why does Ritalin work so quickly for a reuptake inhibitor?

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Ritalin (or DL-methylphenidate, MPH) is a reuptake blocker for both the dopamine and norepinephrine transporters (DAT, NET). In terms of pharmacokinetics, MPH has high (~7%) uptake into the brain and reaches its peak concentration in the brain within 60 minutes[1,2]. read more

For example, Methylphenidate (better known as Ritalin) is a Dopamine Reuptake Inhibitor used to treat ADHD. Many Ritalin users report increased feeling of concentration (dopamine->motivation->concentration), but at the same time feelings of being "robots" and "zombies" - weird feelings that make them feel bad. read more

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