Why does the sickle cell disease cause so much pain?

Sickle cell anemia — Learn about the symptoms, causes, treatment of this inherited blood disorder that, in the United States, is more common among blacks. ... Unexplained episodes of severe pain, such as pain in the abdomen, chest, bones or joints. Swelling in the hands or feet. read more

Hemoglobin SS, also called sickle cell anemia, is usually the most severe type of this disorder. Other common forms include: Hemoglobin SC (usually mild) Hemoglobin Sβ thalassemia; Rare types are: Hemoglobin SD; Hemoglobin SE; Hemoglobin SO; In the U.S., newborn screening programs require that all babies are tested for sickle cell disease shortly after birth. read more