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Why does Typhoid have leukopenia?

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Leukopenia and neutropenia are the main findings in the blood of Typhoid patients.On bone marrow study showed hemophagocytosis with an increased number of histiocytes that had phagocytized most of the neutrophils,rbcs and platelets resulting low count.Hemophagocytosis is seen in other infectious diseases also. read more

Intramedullary destruction of neutrophils and their precursors by non malignant histiocytes is the major cause of leukopenia and/or neutropenia in typhoid. You see, histocytes can engulf nonapoptotic leukocytes, nonsenescent erythrocytes & platelets and thus become hemophagocytes. read more

Leukopenia and/or neutropenia are thought to be characteristic findings in patients with typhoid fever. In a study of 29 children 8 months to 15 years of age mild neutropenia was found in 1 (3%) and leukopenia in 6 (20%) patients. read more

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