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Why don't lysosomes digest their own enzymes?

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This is our first clue to how lysosomes can protect themselves from their own enzymes—if the enzymes can't fit lysosome parts into their active zones, then those lysosome parts are safe. In fact, it is ... Of course, the lysosome contains glycosidases as well, and so those protein shields probably don't last forever. read more

This is our first clue to how lysosomes can protect themselves from their own enzymes—if the enzymes can’t fit lysosome parts into their active zones, then those lysosome parts are safe. In fact, it is known that proteins in the lysosome membrane have an uncommonly large number of sugar molecules stuck to them. read more

Lysosomes are membrane bound cell organelle consisting of Glycosidases, proteases and sulfatases. Lysosome works on the phenomenon of substrate binding. It recognizes certain shapes of molecules which exactly fits with it and then destroy. Hence lysosomes cant recognize the other lysosomes and remain safe. read more

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