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Why don't rodents get atherosclerosis?

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Humans carry about 75% of their plasma cholesterol as low-density lipoprotein (LDL). Mice carry most of their cholesterol on high-density lipoprotein (HDL), which in humans is protective against atherosclerosis. read more

Atherosclerosis is essentially a clogging up of a bold vessel, usually by fat deposits with scarring over the, or by clots of blood. When the clog ( also called a blockage) gets big enough to slow down the flow of blood, the tissue downstream from the blockage dies. read more

In general, atherosclerosis studies in mice involve plaque examination by histologic methods, which necessitate euthanizing the animals. Patients, however, are evaluated as much as possible by noninvasive techniques. read more

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