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Top Ten Most Rare Diseases

Morgellons
Morgellons

Most reports came from California, Texas, and Florida, although patients have been seen in all 50 states. The CDC study found that Morgellons is most likely to affect middle-aged white women. Many of the patients in the CDC study showed signs of being obsessively concerned about health problems in general. This is called somatic concerns.

source: webmd.com
Progeria
Progeria

Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge. Access to this database is free of charge. PubMed is a searchable database of medical literature and lists journal articles that discuss Progeria. Click on the link to view a sample search on this topic.

image: foxnews.com
Water Allergy
Water Allergy

Water allergy to water urticarial is a form of physical urticaria. The characteristic symptom of water allergy is a skin reaction that immediately caused your skin to turn weird like a beehive. It is called as water allergy but it is not actually a true representation of allergy. It is not histamine releasing allergic reaction like most of the other allergies.

Foreign Accent Syndrome
Foreign Accent Syndrome

The said condition, foreign accent syndrome, is considered as rare for which it involves speech changes. The condition is indeed rare for there has been few cases reported for this condition. Accounts of foreign accent syndrome have been noted minimal and have caused great interest among medical practitioners.

source: syndrome.org
image: latestly.com
Laughing Death
Laughing Death

Laughing Death, more commonly known as Kuru, was exclusive to the tribal Fore people of New Guinea. The disease, which was characterized by sudden bursts of maniacal laughter, hit the headlines in the 1950s and drew in doctors from around the world.

source: cnn.com
Fibrodysplasia Ossificans Progressiva (FOP)
Fibrodysplasia Ossificans Progressiva (FOP)

Fibrodysplasia ossificans progressiva (FOP) is a very rare inherited connective tissue disorder characterized by the abnormal development of bone in areas of the body where bone is not normally present (heterotopic ossification), such as the ligaments, tendons, and skeletal muscles.

Alice in Wonderland Syndrome
Alice in Wonderland Syndrome

The hallmark sign of Alice in Wonderland syndrome (AIWS) is a migraine, and AIWS may in part be caused by the migraine. AIWS affects the sense of vision, sensation, touch, and hearing, as well as one's own body image. A prominent and often disturbing symptom are experiences of altered body image.

Hutchinson-Gilford Progeria
Hutchinson-Gilford Progeria

Progeria, or Hutchinson-Gilford progeria syndrome (HGPS), is a rare, fatal, genetic condition of childhood with striking features resembling premature aging. Children with progeria usually have a normal appearance in early infancy.

Fields' Disease
Fields' Disease

Fields' disease is considered to be one of the rarest known diseases in the world, with only two diagnosed cases in history. The frequency of this disease is therefore 1 in approximately 3.75 billion (although since the disease manifested in identical twins, the actual frequency is 1 in approximately 7.5 billion).

Fibrodysplasia Ossificans Progressiva
Fibrodysplasia Ossificans Progressiva

Fibrodysplasia ossificans progressiva (FOP) is a very rare inherited connective tissue disorder characterized by the abnormal development of bone in areas of the body where bone is not normally present (heterotopic ossification), such as the ligaments, tendons, and skeletal muscles.

Von Hippel-Lindau
Von Hippel-Lindau

The role of pregnancy on hemangioblastomas in von Hippel-Lindau disease: a retrospective French study. 9th International Symposium on VHL; October 2010. Rio de Janeiro, Brazil. Peyre M, David P, Van Effenterre R, et al. Natural history of supratentorial hemangioblastomas in von Hippel-Lindau disease. Neurosurgery. 2010;67:577-87.

Microcephaly
Microcephaly

State birth defects tracking systems have estimated that microcephaly ranges from 2 babies per 10,000 live births to about 12 babies per 10,000 live births in the Unites States. 1. Causes and Risk Factors. The causes of microcephaly in most babies are unknown. Some babies have microcephaly because of changes in their genes.

source: cdc.gov
image: drugline.org
Paraneoplastic Pemphigus
Paraneoplastic Pemphigus

Paraneoplastic pemphigus is an extremely rare blistering disease that occurs in individuals who have cancer, especially blood (hematologic) cancers such as leukemia or lymphoma. Paraneoplastic pemphigus is characterized by painful lesions affecting the mucous membranes, especially those found in the mouth and the lips as well as with generalized skin lesions that resemble those seen in erythema multiforme.

image: qatarday.com
Hepatitis-B
Hepatitis-B

Infection around the time of birth or from contact with other people's blood during childhood is the most frequent method by which hepatitis B is acquired in areas where the disease is common. In areas where the disease is rare, intravenous drug use and sexual intercourse are the most frequent routes of infection.

Malaria
Malaria

According to the Centers for Disease Control and Prevention (CDC) in Atlanta, malaria is uncommon in the United States where approximately 1,200 cases are diagnosed each year, usually having been contracted abroad.

Hepatitis-C
Hepatitis-C

But with recent treatment advances, hepatitis C could become rare by 2036, researchers report in the Aug. 5 issue of the Annals of Internal Medicine. "Rare" refers to a disease that affects one in 1,500 people at most, said senior researcher Jagpreet Chhatwal, who conducted the study while at the University of Pittsburgh Graduate School of Public Health. Right now, around one in 100 Americans has chronic hepatitis C.

source: cbsnews.com
Dengue
Dengue

These include dengue hemorrhagic fever, a rare complication characterized by high fever, damage to lymph and blood vessels, bleeding from the nose and gums, enlargement of the liver, and failure of the circulatory system.

source: webmd.com
image: india.com
Tuberculosis
Tuberculosis

Tuberculosis of the Spine (Pott Disease) begins gradually and involves pain in the spinal nerve root and weight loss. More serious cases may cause paralysis. 11.

Ebola
Ebola

Ebola Virus Disease (EVD) is a rare and deadly disease most commonly affecting people and nonhuman primates (monkeys, gorillas, and chimpanzees). It is caused by an infection with one of five known Ebola virus species, four of which can cause disease in people: Ebola virus was first discovered in ...

source: cdc.gov
image: rt.com
Marburg
Marburg

Marburg virus disease is a severe and highly fatal disease caused by a virus from the same family as the one that causes Ebola virus disease. These viruses are among the most virulent pathogens known to infect humans. Both diseases are rare, but have a capacity to cause dramatic outbreaks with high fatality.

source: who.int
Hantavirus
Hantavirus

In Chile and Argentina, rare cases of person-to-person transmission have occurred among close contacts of a person who was ill with a type of hantavirus called Andes virus. People at Risk for Hantavirus Infection. Anyone who comes into contact with rodents that carry hantavirus is at risk of HPS.

source: cdc.gov
Lassa
Lassa

Though there are many forms of pemphigus, paraneoplastic pemphigus is the least common and most serious. PNP is a rare autoimmune bullous disease that causes blistering. Keratinocytes, which are what make up the epidemus, separate from each other, leaving gaps.

source: toptenz.net
image: vox.com
Rabies
Rabies

Rabies is an infectious disease that can affect all species of warmblooded animals, including man. This disorder is transmitted by the saliva of an infected animal and is caused by a virus (Neurotropic lyssavirus) that affects the salivary glands and the central nervous system.

Smallpox
Smallpox

Rare diseases are conditions that affect a small number of people compared to the population as a whole. A disease is considered to be rare when it affects 1 out of 2000 persons. It is also deemed to be scarce in one region but is common in another. There are thousands of rare diseases in the world.

Influenza
Influenza

Most experts believe that flu viruses spread mainly by tiny droplets made when people with flu cough, sneeze or talk. These droplets can land in the mouths or noses of people who are nearby. Less often, a person might also get flu by touching a surface or object that has flu virus on it and then touching their own mouth, nose, or possibly their eyes.

source: cdc.gov
Northern Hairy Nosed Wombat
Northern Hairy Nosed Wombat

Mangy marsupials: wombats are catching a deadly ... the northern hairy-nosed wombat is in the most precarious ... a rare remote image of a wombat coming out its ...

Pygmy Three Toed Sloth
Pygmy Three Toed Sloth

The pygmy three-toed sloth (Bradypus pygmaeus), also known as the monk sloth or dwarf sloth, is a sloth endemic to Isla Escudo de Veraguas, a small island off the coast of Panama. The species was first described by Robert P. Anderson of the University of Kansas and Charles O. Handley Jr., of the Smithsonian Institution in 2001.

Red Crested Tree Rat
Red Crested Tree Rat

The red-crested tree-rat is a species of tree-rat found in the monotypic genus Santamartamys in the family Echimyidae. It is nocturnal and is believed to feed on plant matter, and is mainly rufous, with young specimens having a grey coat.

Angel Shark (Also Known as Squatina Squatina)
Angel Shark (Also Known as Squatina Squatina)

Squatina squatina, the angelshark or monkfish, is a species of shark in the family Squatinidae (known generally also as angel sharks), that were once widespread in the coastal waters of the northeastern Atlantic Ocean.

Elephant Shrew (now Known as Boni Giant Sengi)
Elephant Shrew (now Known as Boni Giant Sengi)

ada Boni Giant Sengi (Formerly Known as an Elephant Shrew) This rare animal lives in the Boni-Dodori Forest in Kenya. The forest these giant sengi call home is being destroyed for development.

source: indulgy.com
image: prideted.com
Southeast Asia's Javan Rhino
Southeast Asia's Javan Rhino

The Javan rhino is smaller than the Indian rhinoceros, and is close in size to the black rhinoceros. It is the largest animal in Java and the second-largest animal in Indonesia after the Asian elephant. The length of the Javan rhino including its head is 2 to 4 metres (6.5 to 13 feet), and it can reach a height of 1.4–1.7 m (4.6–5.6 ft).

Ploughshare Tortoise (Also Known as Angonoka)
Ploughshare Tortoise (Also Known as Angonoka)

The angonoka tortoise (Astrochelys yniphora) is a critically endangered species of tortoise endemic to Madagascar. It is also known as the angonoka, ploughshare tortoise, Madagascar tortoise, or Madagascar angulated tortoise.