Abatacept (Orencia) is often prescribed after failure of a disease-modifying anti-rheumatic agent (DMARD), like methotrexate but it can be used as first-line therapy. Abatacept is used to reduce inflammatory symptoms such as swelling, pain, and stiffness.
Adalimumab, sold under the trade name Humira among others, is a medication used to treat rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn's disease, ulcerative colitis, chronic psoriasis, hidradenitis suppurativa, and juvenile idiopathic arthritis.
Anakinra (Kineret) Anakinra is a biologic drug that may be used to treat rheumatoid arthritis if either the standard medications do not work well or if they cannot be used. A biologic drug is man-made through genetic-engineering techniques and closely related to a protein that occurs naturally in the body.
CIMZIA is a prescription biologic medication that is injected under the skin and works to prevent inflammation that may result from an overactive immune system. In technical terms, it is a PEGylated TNF (tumor necrosis factor) blocker and the first and only PEGylated biologic treatment for moderate to severe rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and moderate to severe Crohn’s disease.
Enbrel ® (etanercept) is a medicine called a biologic. It’s used to treat moderate to severe rheumatoid arthritis, moderate to severe plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, and moderate to severe polyarticular juvenile idiopathic arthritis (JIA).
SIMPONI ARIA ® (golimumab) is a prescription medicine. SIMPONI ARIA ® can lower your ability to fight infections. There are reports of serious infections caused by bacteria, fungi, or viruses that have spread throughout the body, including tuberculosis (TB) and histoplasmosis.
Non-TNFi biologics include Ustekinumab (Stelara®), Secukinumab (Cosentyx®), Abatacept (Orencia®), Tocilizumab (Actemra®), and Rituximab (Rituxan®). Ustekinumab (Stelara®) Ustekinumab (Stelara®) is indicated for adults with plaque psoriasis, psoriatic arthritis, and Crohn’s disease, and adolescents with plaque psoriasis.
Biologic response modifiers, or biologics, target proteins, cells and pathways responsible for triggering the symptoms and damage from autoimmune and inflammatory types of arthritis. The drugs work by interfering with one of the following: tumor necrosis factor (TNF), B cells (a type of white blood cell), T cells (another type of white blood cell) and interleukins (including IL-1, IL-6, IL-12 and IL-23).