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Types of Clotting Disorders

Disseminated Intravascular Coagulation
Disseminated Intravascular Coagulation

Disseminated intravascular coagulation (ko-ag-u-LA-shun), or DIC, is a condition in which blood clots form throughout the body's small blood vessels. These blood clots can reduce or block blood flow through the blood vessels, which can damage the body's organs.

source: nhlbi.nih.gov
Hemophilia B
Hemophilia B

Hemophilia B, also called factor IX (FIX) deficiency or Christmas disease, is a genetic disorder caused by missing or defective factor IX, a clotting protein. Although it is passed down from parents to children, about 1/3 of cases are caused by a spontaneous mutation, a change in a gene.

Liver Disease
Liver Disease

Severe liver disease (eg, cirrhosis, fulminant hepatitis, acute fatty liver of pregnancy) may disturb hemostasis by impairing clotting factor synthesis. Because all coagulation factors are made in the liver, both the PT and PTT are elevated in severe liver disorders.

Other Clotting Factor Deficiencies
Other Clotting Factor Deficiencies

Clotting factors are proteins in the blood that control bleeding. Many different clotting factors work together in a series of chemical reactions to stop bleeding. This is called the clotting process. Problems with factor VIII and factor IX are known as hemophilia A and B, respectively. Rare clotting factor deficiencies are bleeding disorders in which one of the other clotting factors (i.e. factors I, II, V, V + VIII, VII, X, XI, or XIII) is missing or not working properly.

source: wfh.org
Other Factor Deficiencies
Other Factor Deficiencies

Clotting factors are proteins in the blood that control bleeding. Many different clotting factors work together in a series of chemical reactions to stop bleeding. This is called the clotting process. Problems with factor VIII and factor IX are known as hemophilia A and B, respectively. Rare clotting factor deficiencies are bleeding disorders in which one of the other clotting factors (i.e. factors I, II, V, V + VIII, VII, X, XI, or XIII) is missing or not working properly.

source: wfh.org
Overdevelopment of Circulating Anticoagulants
Overdevelopment of Circulating Anticoagulants

Circulating anticoagulants are usually autoantibodies that develop spontaneously (on their own and without a known cause) and decrease the activity of a specific clotting factor (a protein that helps the blood clot) and, therefore, cause excessive bleeding.

Platelet Dysfunction
Platelet Dysfunction

Platelet disorders can involve either a decreased number of platelets (thrombocytopenia) or defective platelet function. Functional disorders of platelets can be inherited (rare) or acquired (common). Platelet aggregation tests are useful in differentiating various disorders of platelet function.

Vitamin K Deficiency
Vitamin K Deficiency

Inherited combined deficiency of the vitamin K-dependent clotting factors (VKCFD) is a very rare inherited bleeding disorder that is caused by a problem with clotting factors II, VII, IX, and X. In order to continue the chain reaction of the coagulation cascade, these four factors need to be activated in a chemical reaction that involves vitamin K.

source: wfh.org
Von Willebrand Disease
Von Willebrand Disease

Rarely, von Willebrand disease can develop later in life in people who didn't inherit an abnormal gene from a parent. This is known as acquired von Willebrand disease, and it's likely caused by another medical condition. Von Willebrand disease has several types: Type 1.

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