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Types of Lactic Acidosis

Acetaminophen
Acetaminophen

Paracetamol (acetaminophen) is one of the most commonly taken drugs in overdose in many areas of the world, and the most common cause of acute liver failure in both the UK and USA. Paracetamol poisoning can result in lactic acidosis in two different scenarios. First, early in the course of poisoning ...

Alcohols and Glycols
Alcohols and Glycols

Lactic acidosis (usually mild) is an uncommon but potentially serious complication. Haemodialysis may be considered if the blood ethanol concentration exceeds 7500 mg/L and severe metabolic acidosis is present. The principal features of severe methanol poisoning are metabolic acidosis and blindness.

Antiretroviral Nucleoside Analogs (Zidovudine, Didanosine, Lamivudine)
Antiretroviral Nucleoside Analogs (Zidovudine, Didanosine, Lamivudine)

In a small pilot study of initial therapy, the triple-nucleoside analogue combination of didanosine + lamivudine + tenofovir, showed virologic failure in 91% of patients at week 12. In 2 studies, the combination of didanosine + tenofovir + efavirenz has demonstrated high rates of early virologic failure in treatment-naive individuals with high HIV RNA and low CD4 levels at baseline. The reasons for the failure of these combinations is not clear; pending further study, they should be avoided.

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