Mayo Clinic researchers are ... degenerative nerve disorders that includes amyotrophic lateral sclerosis ... or Lou Gehrig's disease) Diseases of the neuromuscular ...
Neuromuscular Diseases and Amyotrophic Lateral Sclerosis (ALS) Neuromuscular diseases The difference between ALS-nerve cells and muscle and normal nerve cells and muscle.
What is Charcot-Marie-Tooth disease? Charcot-Marie-Tooth disease (CMT) is one of the most common inherited neurological disorders, affecting approximately 1 in 2,500 people in the United States. The disease is named for the three physicians who first identified it in 1886 - Jean-Martin Charcot and Pierre Marie in Paris, France, and Howard Henry Tooth in Cambridge, England.
What are congenital myasthenic syndromes (CMS)? Like myasthenia gravis (MG), CMS is characterized by weakness and fatigue resulting from problems at the neuromuscular junction— the place where nerve and muscle cells meet (see illustration at right). But while MG is autoimmune, CMS is an inherited disease caused by defective genes.
Congenital myopathy is a very broad term for any muscle disorder present at birth. This defect primarily affects skeletal muscle fibres and causes muscular weakness and/or hypotonia. Congenital myopathies account for one of the top neuromuscular disorders in the world today, comprising approximately 6 in 100,000 live births every year.
Motor neuron disease; Muscle disorders; Muscular dystrophy; Myasthenia gravis; Myotonic dystrophy; Neuromuscular junction disorders; Neuromyotonia (Isaacs syndrome) Peripheral neuropathy; Polymyositis; Research. Doctors are active in clinical and laboratory research to improve the diagnosis and treatment of people with neuromuscular diseases.
Muscular dystrophy is a group of inherited diseases characterized by weakness and wasting away of muscle tissue, with or without the breakdown of nerve tissue. There are 9 types of muscular dystrophy, with each type involving an eventual loss of strength, increasing disability, and possible deformity.
Fibromyalgia is the second most common condition affecting your bones and muscles. Yet it's often misdiagnosed and misunderstood. Its classic symptoms are widespread muscle and joint pain and fatigue.
Glycogen storage disease type II, also called Pompe disease, is an autosomal recessive metabolic disorder which damages muscle and nerve cells throughout the body. It is caused by an accumulation of glycogen in the lysosome due to deficiency of the lysosomal acid alpha-glucosidase enzyme.
Hereditary spastic paraplegia (HSP) is a group of inherited diseases whose main feature is a progressive gait disorder.The disease presents with progressive stiffness and contraction in the lower limbs.
Inclusion-Body Myositis (IBM) What is inclusion-body myositis (IBM)? IBM is one of the inflammatory myopathies, a group of muscle diseases that involves inflammation of the muscles or associated tissues, such as the blood vessels that supply the muscles. A myopathy is a muscle disease, and inflammation is response to cell damage.
The Parkinson's Disease Clinic and Research Center at UCSF is a Center of Excellence designated by the National Parkinson's Foundation since 1992. Conditions Treated Movement Disorders
Although the metabolic muscle diseases characterized by exercise intolerance typically don’t involve muscle weakness, some chronic or permanent weakness can develop in response to repeated episodes of rhabdomyolysis and to the normal loss of strength that occurs with aging.
Muscular dystrophy is a group of inherited diseases characterized by weakness and wasting away of muscle tissue, with or without the breakdown of nerve tissue. There are 9 types of muscular dystrophy, with each type involving an eventual loss of strength, increasing disability, and possible deformity.
In myasthenia gravis, antibodies (immune proteins) block, alter, or destroy the receptors for acetylcholine at the neuromuscular junction, which prevents the muscle from contracting. In most individuals with myasthenia gravis, this is caused by antibodies to the acetylcholine receptor itself.
Skeletal muscle weakness is the hallmark of most myopathies, with some noticeable exceptions, such as myotonia and paramyotonia congenita. In these two inheritable muscular disorders, the muscles become enlarged, rather than weakened and atrophied, and do not relax after contracting.
What is Myositis? Myositis is a term that describes a swelling of the muscles. A temporary form of myositis can be caused by injury, infection, or medicines. The swelling generally stops after the problem is fixed. However, there are also chronic forms of myositis called inflammatory myopathies.
Both polymyositis and dermatomyositis can sometimes be associated with cancers, including lymphoma, breast cancer, lung cancer, ovarian cancer, and colon cancer. The cancer risk is reported to be much greater with dermatomyositis than polymyositis.
Neuromuscular disease (NMD) is a broad term that encompasses many diseases and ailments that impair muscle function, either directly via intrinsic muscle pathology, or indirectly via nerve pathology.
Peripheral neuropathy refers to the conditions that result when nerves that carry messages to and from the brain and spinal cord from and to the rest of the body are damaged or diseased. The peripheral nerves make up an intricate network that connects the brain and spinal cord to the muscles, skin, and internal organs.