Flash's biggest strength is his speed. With speed his muscle strength also grows, simple physics. Faster the objects move, the harder is the impact/collision. Fact that he is one of the fastest characters on DC Earth(not the Universe/Multiverse) helps a lot. read more
Weakness: The Flash can get cut off from the Speed Force. He also has been shown to get mentally overwhelmed in some situations. Flash Barry Allen Post Crisis: Limited Intangibility (Can vibrate his molecules through other materials), Time Travel, Regeneration (Able to regenerate from decapitation. read more
Anyhow, Flash doesn't have a specific weakness. There are things that can affect him (cutting him off from a power source, hurting him traditionally through force) but this applies to any superpowered character. read more
Best Answer: Superman's biggest weakness is 'people'. He would do whatever it takes to safe a human, even Lex Luthor. The Flash is fast,.. even faster than Superman (not all the times). But he still needs to eat, drink, sleep etc. read more