Mechanisms of Action. Evidence exists that milk thistle may be hepatoprotective through a number of mechanisms: antioxidant activity, toxin blockade at the membrane level, enhanced protein synthesis, antifibriotic activity, and possible anti-inflammatory or immunomodulating effects. read more
PHARMACOLOGY AND MECHANISM OF ACTION The mechanisms of action of silymarin are broad and can be summarized as having antioxidant and hepatic effects, renal effects, lipid peroxidation, a reduction in cholesterol synthesis, anti-carcinogenic effects, inhibition of leukotriene production, and insulin inhibition. read more
Milk thistle is indigenous to Europe and Asia but has been naturalized in North and South America. The plant grows 1.5 to 3 m in height and has large, prickly leaves. When broken, the leaves and stems exude a milky sap. read more