A single change in the sequence of amino acids affects how they bond together when they fold in the secondary structure, since amino acids have various properties of bonding, such as polarity, nonpolarity, van der waals interactions, and covalency between the R groups. read more
The linear order of amino acids which make up the protein (also known as primary structure) is important, because it mandates the structural folding of the protein (tertiary structure, or 3D structure), which is linked to the native structure (state) of the end result; the characteristics that allow proteins to function properly within organisms, each with its own role. read more
The order of amino acids in the chain define how these proteins fold. Amino acids can interact with each other by forming disulfide bridges, hydrogen bonds, etc. These all depend on the order of amino acids. read more