Some of the major cities the Mississippi River runs through are St. Paul, Minn.; St. Louis, Mo.; Memphis, Tenn.; and New Orleans, La. The river starts at Lake Itasca in Minnesota and runs 2,320 miles to its mouth in New Orleans at the Gulf of Mexico. read more
The Mississippi River runs from Chicago to St. Louis. On January 1,1900, the city of Chicago reversed the Chicago River and dumped itinto the Mississippi River. read more