Freckles do not have an increased number of melanin-producing cells (melanocytes), but instead have cells that overproduce melanin granules changing the coloration of the skin (increased number of melanosomes). Melanocytes are located in the bottom layer (stratum basale) of skin's epidermis. read more
Normal shedding of skin in humans involves desquamation of the cells (keratocytes) of the outer most layer of the epidermis. Therefore the desquamation wouldn't involve shedding of the melanocytes. Now, the melanocytes responsible for freckles produce excessive amount of melanin following injury commonly due to sunlight. read more