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Are benzodiazepines acids or bases?

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As you can see a benzodiazepine contains tertiary amino groups that act as proton acceptors. IF R1 = H, then we have a secondary amine and a tertiary amine both able to protonate. Therefore they act as bases according to Bronsted and Lowry. read more

It depends on the form. They contain secondary and tertiary amines which can become protonated under the right circumstances. In their “free base” form, they’re unsurprisingly bases. read more

Weak acids/bases only ionize partially when placed in water. Water must normally be present for a substance to be an acid or a base. A base has an excess of H+ ions while an acid has an excess of OH- ions. read more

• acid + acid and base + base = non-ionized • acid + base and base + acid = ionized. Let’s try to look at the pH line and place a weak acid with a pK of 7.9: As seen from this situation a weak acid with a pK of 7.9 placed in an acidic environment, such as the human body (pH = 7.4) it will exists in mostly a non-ionized form. read more

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